Publications

2024

2023

2022

2021

2020

2019

Kim J, Kim R, Lee W, Kim GH, Jeon S, Lee YJ, Lee JS, Kim KH, Won JK, Lee W, Park K, Kim HJ, Im SW, Lee KJ, Park CK, Kim JI, Lee JY. Assembly of glioblastoma tumoroids and cerebral organoids: a 3D in vitro model for tumor cell invasion. Mol Oncol. 2024 Oct 30. doi: 10.1002/1878-0261.13740. PMID: 39473365.
Kang M, Kwon H, Song J, Jang Y, Yang SH, Cha SM, Moon JH, Kim YC, Kim HJ*. Spatial Transcriptomic Signatures of Early Acute T Cell-mediated Rejection in Kidney Transplants. Transplant Direct. 2024 Oct 10;10(11):e1705. doi: 10.1097/TXD.0000000000001705. PMID: 39399058.
Chang SH, Jung S, Chae JJ, Kim JY, Kim SU, Choi JY, Han HJ, Kim HT, Kim HJ, Kim HJ, Park WY, Sparks JA, Lee EY, Lee JS. Therapeutic single-cell landscape: methotrexate exacerbates interstitial lung disease by compromising the stemness of alveolar epithelial cells under systemic inflammation. EBioMedicine. 2024 Oct;108:105339. doi: 10.1016/j.ebiom.2024.105339. Epub 2024 Sep 19. PMID: 39303666.
Yamamura K, Kim HJ, Kim JE. Editorial: Crosstalk: skin cells and immune cells in inflammatory skin diseases. Front Immunol. 2024 Aug 23;15:1472313. doi: 10.3389/fimmu.2024.1472313. PMID: 39247197; PMCID: PMC11377321.
Jin SP, Kim H*, Moon JH, Kim-Schulze S, Chun YS, Nam HJ, Bang YJ, Lee JS, Kim JE, Park CG, Kim HJ, Lee DH. Proteomic analysis of cardiovascular disease-associated proteins in Korean patients with moderate-to-severe atopic dermatitis. World Allergy Organ J. 2024 Aug 8;17(8):100949. doi: 10.1016/j.waojou.2024.100949. PMID: 39220465; PMCID: PMC11363482.
Woo YR, Moon JH, Shin HY, Bang YJ, Song S, Lee S, Lee DH, Kim HJ*, Kim JE*. Systemic Inflammatory Proteomic Biomarkers in Atopic Dermatitis: Exploring Potential Indicators for Disease Severity. J Korean Med Sci. 2024 Aug 12;39(31):e223. doi: 10.3346/jkms.2024.39.e223. PMID: 39137810.
Kang YJ, Song W, Lee SJ, Choi SA, Chae S, Yoon BR, Kim HY, Lee JH, Kim C, Cho JY, Kim HJ, Lee WW. Inhibition of BCAT1-mediated cytosolic leucine metabolism regulates Th17 responses via the mTORC1-HIF1α pathway. Exp Mol Med. 2024 Aug;56(8):1776-1790. doi: 10.1038/s12276-024-01286-z. Epub 2024 Aug 1. PMID: 39085353; PMCID: PMC11372109.
Bang SY, Suh-Yun Joh C*, Itamiya T, Jeong S, Lee JH, Kwon H, Jin H, Jung J, Chung H, Lee BH, Gong JR, Ishigaki K, Fujio K, Bae SC, Je Kim H, Lee HS. Unveiling the dynamics of B lymphocytes in systemic lupus erythematosus patients treated with belimumab through longitudinal single-cell RNA sequencing. Rheumatology (Oxford). 2024 Jul 22:keae364. doi: 10.1093/rheumatology/keae364. Epub ahead of print. PMID: 39037931.
Jin SP, Lee K*, Bang YJ, Jeon YH, Jung S, Choi SJ, Lee JS, Kim J, Guttman-Yassky E, Park CG, Kim HJ, Hong S, Lee DH. Mapping the immune cell landscape of severe atopic dermatitis by single-cell RNA-seq. Allergy. 2024 Jun;79(6):1584-1597. doi: 10.1111/all.16121. PMID: 38817208.
Kim BJ, Shin JS, Min BH, Kim JM, Park CG, Kang HJ, Hwang ES, Lee WW, Kim JS, Kim HJ, Kwon I, Kim JS, Kim GS, Moon J, Shin DY, Cho B, Yang HM, Kim SJ, Kim KW. Clinical Trial Protocol for Porcine Islet Xenotransplantation in South Korea. Diabetes Metab J. 2024 May 21. doi: 10.4093/dmj.2023.0260. Epub ahead of print. PMID: 38772544.
Kook H, Gwag HE, Park SY, Hong N, Lee JH, Jung HJ, Park MY, Choi YS, Kim HJ, Weidinger S, Ahn J. Detecting T-cell receptor clonality in patients with severe atopic dermatitis refractory to dupilumab. J Eur Acad Dermatol Venereol. 2024 Apr 30. doi: 10.1111/jdv.20053
Kim JM, Kang SJ, Hong SH, Chung H, Shin JS, Min BH, Kim HJ, Ha J, Park CG. Long-term control of diabetes by tofacitinib-based immunosuppressive regimen after allo islet transplantation in diabetic rhesus monkeys that rejected previously transplanted porcine islets. Xenotransplantation. 2024 Mar;31(2):e12850. doi: 10.1111/xen.12850.
Chang Gon Kim, Min Hee Hong*, Dahee Kim*, Brian Hyohyoung Lee*, Hyunwook Kim*, Chan-Young Ock*, Geoffrey Kelly, Yoon Ji Bang, Gamin Kim, Jung Eun Lee, Chaeyeon Kim, Se-Heon Kim, Hyun Jun Hong, Young Min Park, Nam Suk Sim, Heejung Park, Jin Woo Park, Chang Geol Lee, Kyung Hwan Kim, Goeun Park, Inkyung Jung, Dawoon Han, Jong Hoon Kim, Junha Cha, Insuk Lee, Mingu Kang, Heon Song, Chiyoon Oum, Seulki Kim, Sukjun Kim, Yoojoo Lim, Seunghee Kim-Schulze, Miriam Merad, Sun Och Yoon, Hyun Je Kim, Yoon Woo Koh, Hye Ryun Kim. A phase II open-label randomized clinical trial of preoperative durvalumab or durvalumab plus tremelimumab in resectable head and neck squamous cell carcinoma. Clinical Cancer Research. 2024 Mar 8. doi: 10.1158/1078-0432.CCR-23-3249. Epub ahead of print. PMID: 38457288.
Suh JH, Choi SY, Huh YJ, Lee JH, Choi SJ, Park CG, Kim HJ, Ujiie H, Jin SP, Kim JE. Spatial transcriptomics of pemphigus vulgaris and bullous pemphigoid: Insights into pathogenesis and therapy on bullous formation. J Eur Acad Dermatol Venereol. 2024 Oct;38(10):e842-e845. doi: 10.1111/jdv.19924. Epub 2024 Mar 3. PMID: 38433529.
Lim Y, Cho BK, Kang SJ, Jeong S, Kim HJ, Baek J, Moon JH, Lee C, Park CS, Mun JH, Won CH, Park CG. Spatial transcriptomic analysis of tumour-immune cell interactions in melanoma arising from congenital melanocytic nevus. J Eur Acad Dermatol Venereol. 2024 Feb 29. doi: 10.1111/jdv.19881.
Brian Hyohyoung Lee, Yoon Ji Bang*, Sung Ha Lim*, Seong-Jun Kang, Sung Hee Kim, Seunghee Kim-Schulze, Chung-Gyu Park, Hyun Je Kim, Tae-Gyun Kim. High-dimensional profiling of regulatory T cells in psoriasis reveals an impaired skin-trafficking property. eBioMedicine. 2024 Feb;1 00:104985. doi: 10.1016/j.ebiom.2024.104985. Epub 2024 Feb 1. PMID: 38306895; PMCID: PMC10847473.
Park S, Kang M, Kim YC, Kim DK, Oh KH, Joo KW, Kim YS, Kim HJ, Moon KC, Lee H. Glomerular spatial transcriptomics of IgA nephropathy according to the presence of mesangial proliferation. Sci Rep. 2024 Jan 26;14(1):2211. doi: 10.1038/s41598-024-52581-8.
Han D, Lee AY, Kim T, Choi JY, Cho MY, Song A, Kim C, Shim JH, Kim HJ, Kim H, D'Angio HB, Preska R, Mayer AT, Kim M, Choi EJ, Kim TG, Shin EC, Park K, Kim DY, Kim SC, Kim JH. Microenvironmental network of clonal CXCL13+CD4+ T cells and Tregs in pemphigus chronic blisters. J Clin Invest. 2023 Dec 1;133(23):e166357. doi: 10.1172/JCI166357.
Christine Suh-Yun Joh, Soyoung Jeong*, Cheol Lee*, Hee Jung Lee, Jung Ho Lee, Hyun Seung Choi, Soyun Cho, Gwangil Kim, Jaehwan Kim, James G Krueger, Chung-Gyu Park, Seon-Pil Jin, Hyun Je Kim, Jung U Shin. Spatial transcriptomic profiling reveals the pathophysiology of early-stage hidradenitis suppurativa. Br J Dermatol. 2023 Aug 17:ljad274. doi: 10.1093/bjd/ljad274. PMID: 37590958.
Jung Ho Lee, Brian H Lee, Soyoung Jeong, Christine Suh-Yun Joh, Hyo Jeong Nam, Hyun Seung Choi, Henry Sserwadda, Ji Won Oh, Chung-Gyu Park, Seon-Pil Jin, Hyun Je Kim. Single-cell RNA sequencing identifies distinct transcriptomic signatures between PMA/ionomycin- and αCD3/αCD28-activated primary human T cells. Genomics Inform. 2023 Jun;21(2):e18. doi: 10.5808/gi.23009. Epub 2023 Jun 30. PMID: 37704208; PMCID: PMC10326540.
Sunho Lee, Sunyoung Jung*, Hyun Je Kim*, Sueon Kim, Ji Hwan Moon, Hyunwoo Chung, Seong-Jun Kang, Chung-Gyu Park. Mesenchymal stem cell-derived extracellular vesicles subvert the Th17 cell by destabilizing RORγt through post-translational modification. Experimental & Molecular Medicine 2023 Apr;55(4):870. doi: 10.1038/s12276-023-01001-4. Erratum for: Exp Mol Med. 2023 Mar;55(3):665-679. PMID: 37100897; PMCID: PMC10167263.
Lim Y, Kang SJ, Cho BK, Kim HJ, Mun JH, Roh MR, Gulati N, Yang HJ, Moon JH, Won CH, Park CG. Intra-tumoral heterogeneity and immune escape of melanoma arising from congenital melanocytic nevus revealed by spatial gene expression profiling. J Eur Acad Dermatol Venereol. 2022 Dec;36(12):e1044-e1047. doi: 10.1111/jdv.18443.
Joo EH, Bae JH, Park JH, Bang YJ, Han J, Gulati N, Kim JI, Park CG, Park WY and Kim HJ. Deconvolution of Adult T-Cell Leukemia/Lymphoma With Single-CellRNA-Seq Using Frozen Archived Skin Tissue Reveals New Subset of Cancer Associated Fibroblast. Front. Immunol. 2022; 13:856363. doi: 10.3389/fimmu.2022.856363.
Dong-Min Kim, Yuri Kim, Jun-Won Seo, Jooyeon Lee, Uni Park, Na-Young Ha, Jaemoon Koh, Hyoree Park, Jae-Won Lee, Hyo-Jin Ro, Na Ra Yun, Da Young Kim, Sung Ho Yoon, Yong Sub Na, Do Sik Moon, Sung-Chul Lim, Choon-Mee Kim, Kyeongseok Jeon, Jun-Gu Kang, Na-Yoon Jang, Hyeongseok Jeong, Jungok Kim, Shinhyea Cheon, Kyung Mok Sohn, Jae Youg Moon, Sungmin Kym, Seung Ro Han, Myung-Shin Lee, Hyun-Je Kim, Woong-Yang Park, Ji-Yeob Choi, Hyun-Woo Shin, Hye-Young Kim, Chung-Hyun Cho, Yoon Kyung Jeon, Yeon-Sook Kim, Nam-Hyuk Cho. Enhanced eosinophil-mediated inflammation associated with antibody and complement-dependent pneumonic insults in critical COVID-19. Cell Rep 2021 Oct 5;37(1):109798. doi: 10.1016/j.celrep.2021.109798. Epub 2021 Sep 20.
Kim HJ, Shim JH, Park JH, Shin HT, Shim JS, Jang KT, Park WY, Lee KH, Kwon EJ, Jang HS, Yang H, Lee JH, Yang JM, Lee D. Single-cell RNA sequencing of human nail unit defines RSPO4 onychofibroblasts and SPINK6 nail epithelium. Commun Biol. 2021 Jun 7;4(1):692. doi: 10.1038/s42003-021-02223-w.
Kim JM, Hong SH, Shin JS, Min BH, Kim HJ, Chung H, Kim J, Bang YJ, Seo S, Hwang ES, Kang HJ, Ha J, Park CG. Long-term control of diabetes in a nonhuman primate by two separate transplantations of porcine adult islets under immunosuppression. Am J Transplant. 2021 May 31. doi: 10.1111/ajt.16704.
Kim J, Lee J, Kim HJ, Kameyama N, Nazarian R, Der E, Cohen S, Guttman-Yassky E, Putterman C, Krueger JG. Single-cell transcriptomics applied to emigrating cells from psoriasis elucidate pathogenic versus regulatory immune cell subsets. J Allergy Clin Immunol. 2021 Apr 29:S0091-6749(21)00662-X.
Park JH, Yoon D, Lee J, Oh SJ, Kim HJ, Lee JH, Lee DY. Clinical profile of cutaneous adverse events of immune checkpoint inhibitors in a single tertiary center. J Dermatol. 2021 Jul;48(7):979-988.
Czarnowicki T, Kim HJ**, Villani AP, Glickman J, Duca ED, Han J, Pavel AB, Lee BH, Rahman AH, Merad M, Krueger JG, Guttman-Yassky E. High-dimensional analysis defines multicytokine T-cell subsets and supports a role for IL-21 in atopic dermatitis. Allergy. 2021 Apr 5.
Hong SH, Kim HJ, Kang SJ, Park CG. Novel Immunomodulatory Approaches for Porcine Islet Xenotransplantation. Curr Diab Rep. 2021 Jan 12;21(1):3.
Park JH, Choi Y, Kim HJ, Oh SJ, Lee DY, Lee JH, Lee JH. Duration of Oral Antibiotics Administration for Cetuximab-Induced Acneiform Eruption. Dermatology. 2021;237(3):457-463.
Kim JM, Hong SH, Chung H, Shin JS, Min BH, Kim HJ, Kim J, Hwang ES, Kang HJ, Ha J, Park CG. Long-term porcine islet graft survival in diabetic non-human primates treated with clinically available immunosuppressants. Xenotransplantation. 2021 Mar;28(2):e12659
He H, Del Duca E, Diaz A, Kim HJ, Gay-Mimbrera J, Zhang N, Wu J, Beaziz J, Estrada Y, Krueger JG, Pavel AB, Ruano J, Guttman-Yassky E. Mild atopic dermatitis lacks systemic inflammation and shows reduced nonlesional skin abnormalities. J Allergy Clin Immunol. 2021 Apr;147(4):1369-1380.
Park JH, Byun HJ, Kim HJ, Oh SJ, Choi C, Noh JM, Oh D, Lee JH, Lee DY. Effect of photobiomodulation therapy on radiodermatitis in a mouse model: an experimental animal study. Lasers Med Sci. 2021 Jun;36(4):843-853.
Chang SH, Kim HJ, Park CG. Allogeneic ADSCs Induce the Production of Alloreactive Memory-CD8 T Cells through HLA-ABC Antigens. Cells. 2020 May 18;9(5):1246.
Lee SJ, Kim HJ*, Byun NR, Park CG. Donor-Specific Regulatory T Cell-Mediated Immune Tolerance in an Intrahepatic Murine Allogeneic Islet Transplantation Model with Short-Term Anti-CD154 mAb Single Treatment. Cell Transplant. 2020 Jan-Dec;29:963689720913876.
He H, Suryawanshi H, Morozov P, Gay-Mimbrera J, Del Duca E, Kim HJ, Kameyama N, Estrada Y, Der E, Krueger JG, Ruano J, Tuschl T, Guttman-Yassky E. Single-cell transcriptome analysis of human skin identifies novel fibroblast subpopulation and enrichment of immune subsets in atopic dermatitis. J Allergy Clin Immunol. 2020 Jun;145(6):1615-1628. (First scRNAseq paper with Human AD skin tissue:
Kim HJ**, Moon JH, Chung H, Shin JS, Kim B, Kim JM, Kim JS, Yoon IH, Min BH, Kang SJ, Kim YH, Jo K, Choi J, Chae H, Lee WW, Kim S, Park CG. Bioinformatic analysis of peripheral blood RNA-sequencing sensitively detects the cause of late graft loss following overt hyperglycemia in pig-to-nonhuman primate islet xenotransplantation. Sci Rep. 2019 Dec 11;9(1):18835.
Chung H, Kim HJ**, Kim JS, Yoon IH, Min BH, Shin JS, Kim JM, Lee WW, Park CG. CD4+ /CD8+ T-cell ratio correlates with the graft fate in pig-to-non-human primate islet xenotransplantation. Xenotransplantation. 2020 Mar;27(2):e12562.
Czarnowicki T, He H, Canter T, Han J, Lefferdink R, Erickson T, Rangel S, Kameyama N, Kim HJ, Pavel AB, Estrada Y, Krueger JG, Paller AS, Guttman-Yassky E. Evolution of pathologic T-cell subsets in patients with atopic dermatitis from infancy to adulthood. J Allergy Clin Immunol. 2020 Jan;145(1):215-228.
Pavel AB, Song T, Kim HJ, Del Duca E, Krueger JG, Dubin C, Peng X, Xu H, Zhang N, Estrada YD, Denis L, Rao N, Gupta S, Zammit DJ, Bissonnette R, Guttman-Yassky E., Oral Janus kinase/SYK inhibition (ASN002) suppresses inflammation and improves epidermal barrier markers in patients with atopic dermatitis. J Allergy Clin Immunol. 2019 Oct;144(4):1011-1024.
Yoon IH, Chung H, Kim HJ**, Nam HY, Shin JS, Kim YH, Park CG. Peri-graft porcine-specific CD4+ FoxP3+ regulatory T cells by CD40-CD154 blockade prevented the rejection of porcine islet graft in diabetic mice. Xenotransplantation. 2019 Sep;26(5):e12533.
Chung H, Hong SJ, Choi SW, Koo JY, Kim M, Kim HJ, Park SB, Park CG. High mobility group box 1 secretion blockade results in the reduction of early pancreatic islet graft loss. Biochem Biophys Res Commun. 2019 Jul 5;514(4):1081-1086.
Czarnowicki T, He H, Leonard A, Kim HJ, Kameyama N, Pavel AB, Li R, Estrada Y, Wen HC, Kimmel GW, Kim HJ, Chima M, Lebwohl M, Krueger JG, Guttman-Yassky E. Blood endotyping distinguishes the profile of vitiligo from that of other inflammatory and autoimmune skin diseases. J Allergy Clin Immunol. 2019 Jun;143(6):2095-2107.
Brunner PM, Israel A, Leonard A, Pavel AB, Kim HJ, Zhang N, Czarnowicki T, Patel K, Murphrey M, Ramsey K, Rangel S, Zebda R, Soundararajan V, Zheng X, Estrada YD, Xu H, Krueger JG, Paller AS, Guttman-Yassky E. Distinct transcriptomic profiles of early-onset atopic dermatitis in blood and skin of pediatric patients. Ann Allergy Asthma Immunol. 2019 Mar;122(3):318-330.e3.